Palonosetron is a 5-HT3 receptor antagonist. It has a strong affinity for this receptor and little for any other type. Blocking this receptor prevents the activation of the vomiting reflex, as it works by blocking serotonin.1
Below is the molecular structure of the 3D conformer Polonosetron.
- 1. Palonosetron. MedlinePlus. 2016. https://medlineplus.gov/druginfo/meds/a610002.html