Creation of Tumor Cells

Scientist working at lab bench

Human epithelial and fibroblast cells are transformed into tumor cells for the first time in a laboratory. This was accomplished by the coexpression of telomerase (hTERT), the simian virus 40 large-T oncoprotein, and an oncogenic allele of H-RAS.1

  • 1. Hahn W.C., et al. "Creation of Tumor Cells With Defined Genetic Elements." Nature. 400 (1999): 464-468. [PUBMED]