Palonosetron

Diagram of the molecular structure of Palonosetron
Brand name: Aloxi®
IUPAC: 3aR)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a, 4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
FDA approval: Yes
Usage:

Palonosetron (Aloxi®) was approved by the FDA in 2003 to help prevent the nausea and vomiting sometimes caused by chemotherapy.1

  • 1. Palonosetron. MedlinePlus. 2016. https://medlineplus.gov/druginfo/meds/a610002.html
Mechanism:

Palonosetron is a 5-HT3 receptor antagonist. It has a strong affinity for this receptor and little for any other type. Blocking this receptor prevents the activation of the vomiting reflex, as it works by blocking serotonin.1

 

Below is the molecular structure of the 3D conformer Polonosetron.

Palonosetron

  • 1. Palonosetron. MedlinePlus. 2016. https://medlineplus.gov/druginfo/meds/a610002.html
Side effects:

Common side effects include: headache, fatigue, diarrhea, dizziness, abdominal pain, trouble sleeping and constipation.1

  • 1. Palonosetron. MedlinePlus. 2016. https://medlineplus.gov/druginfo/meds/a610002.html