Oncogene Table

 

Oncogene Function/Activation Cancer* References
ABL Promotes cell growth through tyrosine kinase activity Chronic myelogenous leukemia 12
AF4/HRX Fusion affects the HRX transcription factor/methyltransferase.  HRX is also called MLL, ALL1 and HTRX1 Acute leukemias 3
AKT-2 Encodes a protein-serine/threonine kinase Ovarian cancer 34
ALK Encodes a receptor tyrosine kinase Lymphomas 5
ALK/NPM Translocation creates fusion protein with nucleophosmin(npm) Large cell lymphomas 6
AML1 Encodes a transcription factor Acute myeloid leukemia 3
AML1/MTG8 New fusion protein created by translocation Acute leukemias 3
AXL Encodes a receptor tyrosine kinase Hematopoietic cancers 3
BCL-2, 3, 6 Block apoptosis (programmed cell death) B-cell lymphomas and leukemias 23
BCR/ABL New protein created by fusion of bcr and abl triggers unregulated cell growth Chronic myelogenous and acute lymphotic leukemia 72
c-MYC Transcription factor that promotes cell proliferation and DNA synthesis Leukemia; breast, stomach, lung, cervical, and colon carcinomas; neuroblastomas and glioblastomas 8
DBL Guanine nucleotide exchange factor Diffuse B-cell lymphoma 3
DEK/CAN New protein created by fusion Acute myeloid leukemia 3
E2A/PBX1 New protein created by fusion Acute pre B-cell leukemia 3
EGFR Cell surface receptor that triggers cell growth through tyrosine kinase activity Squamous cell carcinoma 72
ENL/HRX Fusion protein created by a translocation t(11;19). Acute leukemias 3
ERG/TLS Fusion protein created by t(16:21) translocation.  The erg protein is a transcription factor. Myeloid leukemia 23
ERBB

Cell surface receptor that triggers cell growth through tyrosine kinase activity

Glioblastomas, and squamous cell carcinomas 7
ERBB-2 Cell surface receptor that triggers cell growth through tyrosine kinase activity; also known as HER2 or neu Breast, salivary gland, and ovarian carcinomas 74
ETS-1 Transcription factor Lymphoma 9
EWS/FLI-1 Fusion protein created by  t(11:22) translocation. Ewing Sarcoma 210
FMS Tyrosine kinase Sarcoma 11
FOS Transcription factor for API Osteosarcoma 212
FPS Tyrosine kinase Sarcoma 11
GLI Transcription factor Glioblastoma 13
GSP Membrane associated G protein Thyroid carcinoma 12
HER2/neu overexpression of signaling kinase due to gene amplification Breast and cervical carcinomas 712
HOX11 Transcription factor Acute T-cell leukemia 3
HST Encodes fibroblast growth factor Breast and squamous cell carcinomas 3
IL-3 Cell signaling molecule Acute pre B-cell leukemia 3
INT-2 Encodes a fibroblast growth factor Breast and squamous cell carcinomas 3
JUN Transcription factor for API Sarcoma 412
KIT Tyrosine kinase Sarcoma 412
KS3 Herpes virus encoded growth factor Kaposi's sarcoma 12
K-SAM Fibroblast growth factor receptor Stomach carcinomas 3
LBC Guanine nucleotide exchange factor Myeloid leukemias 1214
LCK Tyrosine kinase T-cell lymphoma 12
LMO1, LMO2 Transcription factors T-cell lymphoma 12
L-MYC Transcription factor Lung carcinomas 34
LYL-1 Transcription factor Acute T-cell leukemia 3
LYT-10 Transcription factor.  Also called NFκB2 B-cell lymphoma 12
LYT-10/Cα1 Fusion protein formed by the (10;14)(q24;q32) translocation of lyt-10  next to  the C alpha 1 immunoglobulin locus.   3
MAS Angiotensin receptor Mammary carcinoma 12
MDM-2 Encodes a protein that inhibits and leads to the degradation of p53 Sarcomas 34
MLL Transcription factor/methyltransferase (also called hrx and ALL1) Acute myeloid leukemia 212
MOS Serine/threonine kinase Lung cancer 315
MTG8/AML1 Fusion of transcription repressor to factor to a transcription factor.  AML1 is also known as RUNX1. Acute leukemias 3
MYB Transcription factor Colon carcinoma and leukemias 3
MYH11/CBFB New protein created by fusion of transcription factors via an inversion in chromosome 16. Acute myeloid leukemia 3
NEU Tyrosine kinase.  Also called erbB-2 or HER2 Glioblastomas, and squamous cell carcinomas 73
N-MYC Cell proliferation and DNA synthesis Neuroblastomas, retinoblastomas, and lung carcinomas 73
OST Guanine nucleotide exchange factor Osteosarcomas 12
PAX-5 Transcription factor Lympho-plasmacytoid B-cell lymphoma 12
PBX1/E2A Fusion protein formed via t(1:19) translocation. Transcription factor Acute pre B-cell leukemia 3
PIM-1 Serine/threonine kinase T-cell lymphoma 12
PRAD-1 Encodes cyclin D1.  Involved in cell cycle regulation. Breast and squamous cell carcinomas 3
RAF Serine/threonine kinase Many cancer types 3
RAR/PML Fusion protein caused by t(15:17) translocation.  Retinoic acid receptor. Acute premyelocytic leukemia 73
RAS-H G-protein. Signal transduction. Bladder carcinoma 3
RAS-K G-protein. Signal transduction Lung, ovarian, and bladder carcinoma 34
RAS-N G-protein. Signal transduction Breast carcinoma 3
REL/NRG Fusion protein formed by deletion in chromosome 2. Transcription factor. B-cell lymphoma 34
RET Cell surface receptor. Tyrosine kinase Thyroid carcinomas, multiple endocrine neoplasia type 2 73
RHOM1, RHOM2 Transcription factors Acute T-cell leukemia 3
ROS Tyrosine kinase Sarcoma 12
SKI Transcription factor Carcinomas 12
SIS Growth factor Glioma, fibrosarcoma 12
SET/CAN Fusion protein formed by rearrangement of chromosome 9.  Protein localization Acute myeloid leukemia 1216
SRC Tyrosine kinase Sarcomas 317
TAL1, TAL2 Transcription factor.TAL1 is also called SCL Acute T-cell leukemia 318
TAN-1 Altered form of Notch (a cellular receptor) formed by t(7:9) translocation Acute T-cell leukemia 319
TIAM1 Guanine nucleotide exchange factor T-lymphoma 1220
TSC2 GTPase activator Renal and brain tumors 1221
TRK Receptor tyrosine kinase Colon and thyroid carcinomas 322

* The cancer types listed in this column are those that are predominantly associated with each oncogene but this is not a complete list.

For information on these and other genes please visit the Cancer Genome Anatomy Project.

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