Skin Cancer

Malignancies of the skin are the most commonly diagnosed cancer type worldwide.1 The foremost cause of skin cancer remains UV radiationIn cancer biology: A cancer treatment in which high energy beams are used to kill cancer cells. Radiation can also cause genetic damage that can lead to cancer. As an example, skin cancer is believed to be greatly increased by exposure to ultraviolet (UV) radiation from the sun. from sunlight. However, this disease, classically seen in older adults, is becoming increasingly common in younger populations due to tanning beds and exposure to other cancer causing elements. Skin cancer may be classified as either non-melanoma skin cancer (cancer types include squamous cell carcinomaCancer of epithelial cells, the cells that cover the outside and inside of body surfaces. This is the most common form of cancer. and basal cell carcinoma) or melanoma. The most common type of skin cancer is basal cell carcinoma. However, melanoma which accounts for only 4% of skin cancer is responsible for 80% of skin cancer deaths.1

The incidence of skin cancer is very high. It is the most diagnosed of all cancers. However, there aren't many exact numbers because the cases of basal cell and squamous cell skin cancers aren't required to be reported to cancer registries, partly because of their low lethality and very high curability rate. At the least, it is known that over 2 million people were treated for these cancers in 2006. Melanomas, on the other hand, have a very high mortality rate that has been increasing over the several decades, especially among younger women and the elderly, so there is much more data on this. In 2015, it is estimated that there will be 73,870 new cases of melanoma and 6,230 new cases of other non-epithelialA type of tissue (epithelium) that covers our exposed surfaces, such as skin. Also lines our hollow or tube-like organs/tissues such as the digestive tract. Since these tissues are often exposed to environmental insults such as chemicals and solar radiation and are often divide rapidly to replace lost cells, many cancers arise in epithelial tissues. skin cancers, with 9,940 deaths for melanoma and 3,400 deaths for non-epithelial.2

Young men DO get cancer. View the clip and then watch an interview with Philip Groom, a skin cancer survivor diagnosed when he was 16 years old.

Please visit the following sections to learn more about skin cancer.

Skin Cancer Education:
CancerQuest, with help from the Melanoma Group at the Winship Cancer Institute of Emory University, has developed a skin cancer curriculum. The curriculum is available free for educational (non-profit) uses. View/Download the curriculum.

Learn more about skin cancer or make an appointment at the Winship Cancer Institute of Emory University.

Anatomy Of The Skin

The skin is one of the largest organs of the body3 and is responsible for providing protection to the other systems of the body. Skin prevents water loss and dehydration, shields the internal organs in the event of injury, regulates body temperature, senses outside stimuli such as touch as well as heat and cold, and serves as a barrier to infection.4 As seen below, the skin is made up of three layers: the outer epidermis, the dermis and the deep subcutis layer. Other important elements of the skin include: hair follicles, sweat glands and nerve endings. Hair follicles protrude into the dermis layer and help regulate body temperature. Microscopic pores on the surface of the skin are connected to sweat glands which also help maintain homeostasis.

SkinLabels.png

The pigments that color skin are produced by cells called melanocytes . Melanocytes, located in the epidermis (specifically in the stratum basale as seen in the diagram above), synthesize melanin which determines the color of the skin, hair and eyes.5 An individual's skin color is determined by their genes and their environment (primarily sun exposure). Our skin can change color in reaction to sun exposure. This is called the "tanning response." When skin absorbs UV radiation, melanin is produced and transferred to keratinocytes altering (darkening) the color of the skin.6Melanin in the skin absorbs and scatters UV radiation entering the body and helps protect the skin from adverse reactions to radiation, such as DNAAbbreviation for deoxyribonucleic acid. Composed of very long strings of nucleotides, which are abbreviated as A, C, G and T. DNA is the storage form of our genetic material. All of the instructions for the production of proteins are encoded in our DNA. damage (geneA stretch of DNA that leads to the production of an RNA. The RNA is produced during the process of transcription. This RNA can be used to guide the formation of a protein via translation or can be used directly in the cell. mutation). Viewed this way, the "tanning response" is really a defensive reaction by the body to the presence of damaging radiation.5

Learn more about skin cancer or make an appointment at the Winship Cancer Institute of Emory University.

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Types Of

Skin cancer may be divided into two types: non-melanoma and melanoma.

Non-melanoma Skin Cancer
There are two major sub-types of non-melanoma skin cancer:

  • Basal Cell Carcinoma- The most commonly diagnosed skin cancer. Tumors often develop on regions of the body that receive regular sun exposure such as the face and hands. Due to its slow growth rate, basal cell carcinoma rarely spreads and is usually treatable.7 A common form of basal cell carcinoma is nodular basal cell. Lesions appear as a pearly nodules in various colors including brown, black and blue.8

    Some examples:
     
    face bccear bccface bccbcc
    Images used courtesy of the Skin Cancer Foundation.

     
  • Squamous Cell Carcinoma- Appears on body parts that experience increased levels of sun exposure such as the face, lips and back.7 This cancer is more likely to spread than basal cell carcinoma. The cancerous lesions have numerous forms. They may be rough, scaly, lumpy or flat. Blood vessels may appear at the edge of a lesionThis is a broadly used term in pathology and refers to any defined (localized) structural abnormality or injury. The word 'lesion' does not imply that something (i.e. a tumor) is necessarily serious or advanced. causing it to bleed easily.7

    Some examples:
     
    finger nail scclip sccnose scchand scc
    Images used courtesy of the Skin Cancer Foundation.

Melanoma Skin Cancer
Melanoma is a cancerous growth of melanocytes and most frequently develops in the skin.1 Melanoma may also develop in other parts of the body that contain melanocytes including the meninges, the digestive tract, the eyes and lymph nodesA grape-like cluster of lymphatic tissue. Lymph nodes (or lymph glands) filter the lymph fluid that flows through the lymphatic system. Lymph nodes collect fluid from discrete regions of the body and are often examined for the presence of metastasizing cancer cells.. The following descriptions are limited to melanoma of the skin.

There are several types of melanoma that can be categorized based on their appearance, either with the naked eye or microscopically:

  1. Superficial spreading: The most frequently observed melanoma. This form may develop in any region of the skin. Lesions are usually raised around the edges and a brown color with hints of pink, white, gray and blue.
  2. Nodular type lesions: Also arise on all regions of the body and are typically black or brown in color.
  3. Acral lentiginous lesions: Characterized by flat, brown or black tumors that often develop on the hands and feet.
  4. Lentigo maligna melanoma: Develop on an individual's face. Distinguished by its irregular border and tan to brown color.9

Some examples of melanomas that demonstrate the irregular shapes and colors often encountered:
 

melanoma facemelanomamelanomamelanoma
Images used courtesy of the Skin Cancer Foundation.

Learn more about skin cancer or make an appointment at the Winship Cancer Institute of Emory University.

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Risk Factors

The following risk factors that influence one's risk of developing skin cancer are discussed below:

  • Ultraviolet Radiation 1
  • Skin Color 9
  • Sun Sensitivity
  • Immunosuppression
  • Prior Diagnosis8
  • Family History
  • Radiation Therapy10
  • Smoking 7
  • Chemical Exposure 7
  • Drugs used to treat other conditions11
  • Injury 7
  • Geographic Location
  • Infection with HPV? 12

Ultraviolet Radiation

Overexposure to ultraviolet (UV) radiation may cause genetic changes (mutations) in skin cells. The genetic changes cause the affected cells to alter their behavior and may result in cancer.1 Sources of UV radiation include the sun and tanning beds. Ultraviolet radiation also induces the production of very reactive chemicals, oxidants, in affected cells.1 Oxidants cause some of the changes associated with aging and increase one's risk of developing cancer.

Tanning beds are a dangerous source of UV radiation. They have been associated with all major types of skin cancer - basal cell carcinoma, squamous cell carcinoma, and melanoma. Tanning beds have been designated as a cancer causing agent by the World Health Organization.1314 The use of a tanning bed increases a person's risk of developing melanoma, regardless of whether or not the person gets sunburned.15

Below is a diagram showing the radiation from the sun and which parts make it to the surface of the earth. This graphic is interactive, so click on the different boxes to see the penetration of different types of light (including UV) and to see the layers of the atmosphere.

Skin Color & Sun Sensitivity

Fair skin is more susceptible to ultraviolet radiation damage.9 Caucasians, specifically individuals with freckles, light eyes and/or red hair, are at higher risk of skin damage that may lead to skin cancer.9

Immunosuppression

Immunosuppressants weaken the action and efficacy of the immune system and hinder its ability to fight foreign invasion. 1Immunosuppression may support the development of cancer.  A weakened immune system is less able to eliminate cells that have suffered mutations and have the potential to develop into cancer cells.  In addition, immunosuppressant therapies may have direct cancer causing consequences.16

Drugs used to treat other illnesses

Thiopurines, a class of drugs used to treat inflammatory diseases (i.e. Crohn's disease and inflammatory bowel syndrome) and some forms of cancer, has been shown to increase risk for the development of non-melanoma skin cancers.11

Personal History

Survivors of skin cancer have an increased risk of developing a secondary cancer.1 The greatest risk for relapse is within the first five years following treatment. This heightened risk may be a result of a biological predisposition, previous exposure to skin cancer risks or a consequence of the initial cancer treatment itself. 

Radiation Therapy

Radiation therapy is often used in the medical field in the treatment of primary cancers.  Irradiation of primary tumors often exposes normal skin to increased levels of radiation and may lead to the development of secondary cancers, including skin cancer.  The cancers arise due to mutations within skin cells caused by high doses of radiation. 10

Chemical Exposure

Chronic exposure to arsenic, industrial tar and paraffin may increase one's risk of developing skin cancer.7

Serious injury

In some instances, skin cancer development is associated with serious injury or inflammationA reaction to tissue damage or invasion. Small blood vessels become leaky, leading to redness and swelling. Cells of the immune system migrate to the area and can release chemicals and proteins that cause damage to the structures/cells nearby..7  MalignantA tumor that has invaded neighboring tissue. growths that arise at sites of previous serious/chronic wounds such as burns and pressure ulcers are termed Marjolin ulcers.17

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Risk Factors For Melanoma

Risk factors specific to melanoma:

  • Sun Burn
  • Prior Diagnosis1
  • Family History 9
  • Melanocytic Nevi 9

Watch the video below to learn about some great skin cancer prevention tips. Watch the full interview with Dr. Suephy Chen.

Sun exposure:
Sun exposure increases one's risk of skin cancer. Individuals are inevitably exposed to sunlight, or ultraviolet radiation, during their daily activities. However, certain outdoor behaviors elevate an individual's likelihood of developing cancer. Infrequent, but intense exposure to sunlight during childhood increases one's risk of developing melanoma. 1 Melanoma is often observed on areas of the body that receive infrequent, but intense sun exposure such as the neck and the back of the legs. 18

Also, it is important to note that cutaneous melanoma may occur in regions of the body typically shielded from sunlight such as the groin and bottom of the feet.

Family History
Individuals who have first degree relatives, including parents, siblings or children, diagnosed with melanoma have an 8 to 12 fold increased chance of developing melanoma. 9 This increased risk is likely due to a biological predisposition to cancer development.

Melanocytic Nevi
The medical term for a marking on the skin, such as a mole or birthmark, is "nevus" (plural-nevi). Most melanocytic nevi develop during childhood and adolescence as a result of sun burn and sun exposure. The presence of melanocytic nevi is associated with an increased risk of developing melanoma.9

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Symptoms And Detection

The American Academy of Dermatology and the American Cancer Society recommend that individuals perform monthly self-examinations.9  It is important to keep the ABCDE's (Asymmetry, Border, Color, Diameter, Evolution) of melanoma in mind.:

  • Asymmetry: melanomas tend to be asymmetrical while benignA growth that does not leave its site of origin or invade surrounding tissue. Benign growths can get large and are capable of causing illness or even death, depending on the location of the growth. Technically, benign growths are not cancer. lesions are more rounded and symmetric.
  • Borders: Benign lesions are usually regular and flush with the skin while melanomas may have irregular and/or raised borders.
  • Color: Melanomas may be tan, black or brown and often include regions of red, white and blue.
  • Diameter: In general, melanomas are larger than 6 mm in diameter.
  • Evolution: Changes in physical appearance of melanocytic growths are often observed over time and skin marking should be monitored for changes. Because the changes may be gradual, it is a good idea to photograph any suspicious marks, including a ruler or coin for size comparison. This allows for direct comparison of images taken at different times.

Although the ABCDE guidelines assist with a valuable screening tool, it is important to see a physician regularly and especially if one finds a suspicious or irregular skin marking/growth or witnesses a change in an existing skin marking/growth.9

 

Asymmetry:
asymmetrical

Border:
irregular border

Color:
abnormal color

Diameter:
diameter


Images used courtesy of the Skin Cancer Foundation

Click here for information about melanoma treatments and services at the Winship Cancer Institute of Emory University.

An imaging system, MelaFind®, developed by Mela Sciences has been approved by the FDA to aid in the detection of melanoma.19  Learn more about MelaFind®.

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Melanoma Staging

Pathology Report & Staging
Staging is a powerful tool for treatment plan development and risk assessment in individual patients.  Staging also enables physicians to communicate with each other regarding patients' diseases and insure equal standards of care for patients with similar disease states. 20 The American Joint Committee on Cancer (AJCC) has developed a staging system for nonmelanoma and melanoma skin cancer.9

Staging of skin cancer is based on the TNM staging described in the CancerQuest section on Cancer Staging. Using this information, physicians may determine the stage of disease. The information below is specific for melanoma:

  • Stage I: The disease is localized to a primary tumorThe initial tumor mass formed by the abnormal growth of a cell. The primary tumor determines the type of cancer. When the initial tumor spreads to other locations, the metastatic growths retain the characteristics of the initial, primary, tumor. As an example, if the initial site of cancer development is in the breast, then a metastatic growth in the brain would still be considered breast cancer, NOT brain cancer. site. The majority of diagnoses are during this stage.20
  • Stage II: The disease is more developed, but remains localized to the original site.21
  • Stage III: The disease has spread regionally; doctors often examine the number and location of invaded lymph nodes. 20
  • Stage IV: The melanoma has spread to distant organs.20

Several different approaches to staging of melanoma have been developed. Two criteria that have been used extensively include the categorization of melanomas according to their 'Clarks' levels' or 'Breslow thickness'. The Clark level is based on the layers of epidermis that the tumor has penetrated at the time of measurement. Breslow thickness measures the absolute distance of tumor penetration into the epidermis (measured in millimeters (mm)).

The Breslow tumor thickness evaluation system measures tumor thickness in mm from the top of the granular layer to the deepest tumor growth. The Breslow scale divides melanomas into four classes:

  • T1 1mm or less; "Thin melanoma"
  • T2 1-2 mm
  • T3 2-4 mm
  • T4 greater than 4mm depth; "Thick lesions"2223

The "Clark levels of invasion" system, named after the developer, pathologist, Wallace Clark, was the first widely accepted method for staging of melanomas.  It is considered a reliable staging system today, and tumors are classified as one of five categories. It is important to note that Clark levels are NOT the same as the stage of the disease.

  • Level I Lesions: Melanoma restricted to the epidermis also known as an in situFrom the Latin, "in place", often written in italics. Refers to the detection of a process or molecule which is examined in its original location. This is in contrast to in vitro which refers to processes or molecules examined in test tubes. melanoma.
  • Level II Lesions: Melanoma crosses the epidermis and invades the papillary dermis. This may be referred to as the micro invasive radial growth phase.
  • Level III Lesions: The entry into the true tumor phase in which the tumor grows to fill the papillary dermis region. Such tumors have entered the vertical growth phase.
  • Level IV Lesions: Tumor cells overcome barriers of the papillary dermis- reticular dermis barrier, invading the reticular dermis region.
  • Level V Lesions: Tumor growth extends into the subcutaneous fat.2223

More advanced disease is generally associated with a decreased survival rate.20

View detailed staging information from the National Comprehensive Cancer Network (NCCN).

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Tumor Biology

 Genetic changes that occur in cancer cells include mutation of key regulatory genes, changes in proteinOne of the four basic types of biomolecule. Proteins are polymers made up of strings of amino acids. Proteins serve many functions in organisms including transport of molecules, structure, cell adhesion and as signaling molecules such as hormones. Many transcription factors, including p53 and Rb are proteins. products, and changes in the amount of product produced by genes (gene expressionThe act of transcription and, if needed, translation of a gene. Regulation of gene expression is tightly regulated. Genes must only be expressed in the correct cells, at the right time and in the correct amount. Abnormal gene expression is always found in cancer cells.). As changes accumulate, cells become more abnormal and cancer may result. Details of genetic change associated with cancer can be found in the Mutation section. Some of the genetic elements that have been shown to be important in the development of skin cancer are discussed below:

MC1R Gene and α-melanocyte-stimulating hormoneA chemical produced by cells that alters the activity of other cells. The chemicals may be lipids, such as testosterone and estrogen or proteins like insulin. Hormones may act at locations far from their site of origin. Estrogen, for example, is produced primarily by cells in the ovaries but acts on cells in the breast and elsewhere.
The melanocortin receptor is responsible for binding alpha-melanocyte-stimulating hormone, the signal that initiates melanin production. Fair skinned individuals have polymorphisms which reduce the affinity of MC1R resulting in decreased MC1R:alpha-MSH binding. As a result, melanin production is reduced, increasing the individual's risk of developing melanoma. 24

CDKN2A
CDKN2A refers to a region of DNA coding for two tumor suppressorA gene that functions in the control of cell division. Tumor suppressors normally work to limit cell division and may be contrasted with oncogenes. proteins:
Ink4A and Arf. Both proteins play a key role in cell cycle regulation. Reduced activity of these proteins has severe consequences on the ability of cells to regulate cell division. Mutations in CDKN2A result in reduced function of the p53A tumor suppressor gene that is mutated in over 50% of cancers of all types. The p53 protein is a transcription factor that controls entry into the cell division cycle. Many signals about the health of a cell are relayed to the p53 protein. This results in a decision by the cell as to whether or not cell division should occur. If the cell is damaged and can not be repaired, the p53 protein is involved in triggering a chain of events that causes the cell to kill itself in a process termed apoptosis. Cells defective for p53 do not have these controls and tend to divide even when conditions are not favorable. Like all tumor suppressors, the p53 gene is normally involved in slowing or monitoring cell division. and RBA tumor suppressor. The Rb gene is mutated in many different cancers but was initially described due to its role in the development of an eye cancer, retinoblastoma, which usually strikes young children. The protein product of the gene is a transcription factor that controls the expression of genes important in driving cells into the division process. tumor suppressor pathways. 25

RASA proto-oncogene that is found to be mutated in many different kinds of cancer. The ras protein is involved in transmitting signals through the cell that drive the cell into the division process. Genes
RAS refers to a group of genes which are often mutated in cancer of many different types, melanoma included. The protein products are involved in transmitting signals through cells (also called "signal transduction") and are involved in numerous processes. Mutated RAS may increase malignant cell proliferationRefers to cell division. The proliferation rate is an indicator of how quickly a tumor is growing. The proliferation rate may be represented as a percentage, showing what fraction of the cells are actively involved in the division process. and reduce apoptosisAlso called programmed cell death. Apoptosis is a natural process that occurs throughout the lives of almost all animals and plants. The death of the cells is a carefully controlled process that does not generate any inflammation.. The pathways controlled by RAS have been found to be very frequently disrupted in melanoma cells.25

RAF Genes
The products of the three known RAF genes (RAF-1, ARAF and BRAF) function in the RAS pathway. The proteins are serine/threonine kinases and they function to transmit signals through the cell, influencing cell division. The BRAF gene product also seems to be involved in cell death (apoptosis). In one study, mutations in BRAF genes were observed in 66% of melanoma cell lines examined. 2526

Bcl-2A protein that works to inhibit apoptosis (cell death). The gene was initially identified in a B cell lymphoma, from which it got its name.
This gene encodes a protein that regulates apoptosis. Mutations which increase expression of Bcl-2 or enhance its function tend to reduce cell death and favor cancer development. 25

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Treatment

Both surgical and non-surgical approaches are used in the treatment of melanoma and non-melanoma skin cancers. 8 Treatment of non-melanoma skin cancer is made more difficult by the high frequency of recurrence. 27 For advanced melanoma, a highly successful treatment option for advanced disease has not yet to be identified. 27

Surgical Treatment

Excision of a skin cancer lesion is a frequent treatment option.  Excision may be curative for diseases that are in stages I or II (localized). 9

Non-surgical Treatment

Alternate treatment methods are preferred for patients whose health does not allow them to enter into surgery or for patients with cancerous lesions located in regions difficult to access surgically.  Patients who undergo surgery may receive additional treatments. 27Examples of nonsurgical treatment options include:

  • Radiotherapy - the use of high energy waves, such as x-rays, to kill cancer cells.

    Learn more about radiotherapy.

  • Photodynamic Therapy - a type of treatment in which an "inactive" medication is applied to the area of interest and then "activated" by exposure to specific wavelengths of light.  In the case of skin cancer, the agent may be applied directly to the skin in the form of a liquid. 28
  • Topical Drug Treatments: an ointment containing imiquimod (Aldara™) has been used to treat basal cell carcinoma, genital warts and actinic keratosis.  Imiquimod is an immune response modifier that stimulates the immune system to eliminate cancer cells. View the package insert.

    Learn about the immune response and cancer.
    Learn more about Aldara™ from the manufacturer.

  • Biological Treatments: biological treatments for melanoma include the use of interleukin 2 (IL-2).

    Learn about biological response modifiers and cancer.

  • Specific Inhibitors: KinaseAn enzyme that adds phosphate groups to another molecule. Many key proteins controlling gene expression are kinase targets. Addition of a phosphate group to a protein can alter the activity of the protein and are often used as molecular on/off switches. For example, the retinoblastoma tumor suppressor gene is 'off' when phosphate groups are added to the protein at specific locations. Removal of the phosphate groups turns the protein 'on'. Enzymes that remove phosphate groups are known as phosphatases. Note that all enzymes, regardless of function, end in ASE inhibitors, including sorafenib (Nexavar®) are being evaluated for treatment of advanced melanoma.

    Learn more about specific inhibitors.
    Learn more about kinase inhibitors, including sorafenib (Nexavar®).
    Learn more about Nexavar® from the manufacturer.

More Information

For information about how these and other cancer treatments work, refer to the Cancer Treatments section.

Learn more about Melanoma treatment at the Winship Cancer Institute of Emory University.

Information about clinical trials:

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Resources

Internet Resources:

Winship Cancer Institute: Melanoma Diagnosis and Staging         Make an Appointment

Aim at Melanoma

Melanoma Patients' Information Page

Interactive Skin Cancer Tutorial

American Academy of Dermatology

Skin Cancer Foundation

 

Melanoma Resources:

Melanoma Center

Melanoma Education Foundation

Melanoma International Foundation

Melanoma Research Foundation

 

Publications From the National Cancer Institute:

What You Need To Know About: Moles and Dyplastic Nevi

What You Need to Know: Skin Cancer

 

Publications From Other Resources:

Basal and Squamous Cell Skin Cancer (ACS)

Melanoma Skin Cancer (ACS)

Why You Should Know About Melanoma (ACS)

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Section Summary

Introduction

  • Malignancies of the skin are the most commonly diagnosed cancer type worldwide.
  • Skin cancer is becoming increasingly common in younger populations.

Types of Skin Cancer

  • Skin cancer can be divided into two types: melanoma and non-melanoma.
  • Non-melanoma skin cancer has two major sub-types: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
  • Basal cell carcinoma is the most commonly diagnosed skin cancer.
  • Melanoma is a cancerous growth of melanocytes and most frequently develops in the skin.

Risk Factors

  • Overexposure to UV radiation causes genetic damage that can promote skin cancer development.
  • Fair skin is more susceptible to ultraviolet radiation damage.
  • Survivors of skin cancer have an increased risk of developing a second cancer.
  • Exposure to certain chemicals and radiation increase the risk for skin cancer.

Symptoms and Detection

  • The ABCDEs of skin cancer assist in early detection: Asymmetry, Border, Color, Diameter, Evolution

Pathology Report and Staging

  • T/N/M staging is used in skin cancer. This system assigns a degree of severity based on size, lymph node involvement, and spread of the cancer.
  • Other skin cancer staging systems consider the depth of penetration of the tumor into the epidermis.

Skin Cancer Tumor Biology

  • Many genetic changes occur in cancer. Details can be found in the Mutation section.
  • Genes that have been implicated in the development of skin cancer include MC1R, CDKN2A, RAS, RAF, and Bcl-2.

Treatment

  • BCC and SCC are frequently removed via minor surgery.
  • Early-stage melanomas can be surgically removed.
  • Non-surgical treatments for skin cancer include: chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division., radiotherapy, topical drug treatments, biological treatments and specific inhibitors.

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Know The Flow: Melanoma

Know the Flow is an educational game for you to test your knowledge. To play:

  • Drag the appropriate choices from the column on the right and place them in order in the boxes on the left. Note that you will only use five of the six choices to complete the game.
  • When done, click on 'Check' to see how many you got correct.
  • For incorrect answers, click on 'Description' to review information about the processes.
  • To try again, choose 'Reset' and start over.

Know the Flow: Melanoma

Processes in order

  • 1
  • 2
  • 3
  • 4
  • 5

Processes

  • Learn more
    Intense UV Radiation Exposure
  • Learn more
    Skin Gets Tan or Burned
  • Learn more
    Mutation of Regulatory Gene in Melanocyte
  • Learn more
    Abnormal Cell Division
  • Learn more
    A New "Abnormal" Looking Mole Forms
  • Learn more
    Rash Forms on Skin Surface

You did it!

The process is in the correct order!

Learn more about skin cancer or make an appointment at the Winship Cancer Institute of Emory University.

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Pick A Part: The Skin

Pick A Part is an interactive game for you to test your knowledge. To play:

  • Drag the appropriate choices from the column on the bottom and place them in order in the boxes on the left. Note that you will only use five of the six choices to complete the game.
  • When done, click on 'Check' to see how many you got correct.
  • For incorrect answers, click on 'Description' to review information about the processes.
  • To try again, choose 'Reset' and start over.

Pick a Part: Skin

  • 1
  • 2
  • 3
  • 4
  • 5

Choices

  • Learn More
    Hair
  • Learn More
    Epidermis
  • Learn More
    Dermis
  • Learn More
    Sweat Gland
  • Learn More
    Subcutaneous
  • Learn More
    Mesoderm

Well done!

You picked the parts correctly!

For help please refer to the Anatomy of the Skin page.

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Get It Together: The Skin

The jigsaw puzzle below is timed. See how quickly you can build the skin model shown below the puzzle!

labeled skin

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Save The Surfer

Save the Surfer! Test your knowledge of skin cancer by answering before the sun's rays hit the surfer. If you need more time, put on some sunscreen!

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  • 1. a. b. c. d. e. f. g. h. i. j. Miller AJ, Mihm MC Jr. "Melanoma." New England Journal of Medicine. 2006 Jul 6;355(1):51-65. [PUBMED]
  • 2. American Cancer Society. Cancer Facts & Figures 2015. Atlanta: American Cancer Society; 2015. [http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdf]
  • 3. Goldsmith LA. My organ is bigger than your organ. Arch Dermatol. 1990 Mar;126(3):301-2. [PUBMED]
  • 4. Vander's Human Physiology: The Mechanisms of Body Function, 10/e. Eric P. Widmaier, Hershel Raff, Kevin T. Strang. 2006. McGraw-Hill Inc: New York, New York.
  • 5. a. b. Meredith P, Sarna T. "The physical and chemical properties of eumelanin." Pigment Cell Research. 2006 Dec; 19(6): 572-94. [PUBMED]
  • 6. Tsatmali M, Ancans J, Thody AJ. "Melanocyte function and its control by melanocortin peptides." Journal of Histochemistry and Cytochemistry. 2002 Feb;50(2):125-33. [PUBMED]
  • 7. a. b. c. d. e. f. g. h. Holcomb SS. "Nonmelanoma skin cancer." Nursing. 2006 Jun;36(6):56-7. [PUBMED]
  • 8. a. b. c. Rubin AI, Chen EH, Ratner D. "Basal-cell carcinoma." New England Journal of Medicine. 2005 Nov 24;353(21):2262-9. [PUBMED]
  • 9. a. b. c. d. e. f. g. h. i. j. k. l. Rager EL, Bridgeford EP, Ollila DW. "Cutaneous melanoma: update on prevention, screening, diagnosis, and treatment." American Family Physician. 2005 Jul 15;72(2):269-76. [PUBMED]
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