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Oncogene Table


Oncogene Function/Activation Cancer* References
abl Promotes cell growth through tyrosine kinase activity Chronic myelogenous leukemia (1)(2)
Af4/hrx Fusion affects the hrx transcription factor/methyltransferase.  hrx is also called MLL, ALL1 and HTRX1 Acute leukemias (3)
akt-2 Encodes a protein-serine/threonine kinase Ovarian cancer (3)(4)
alk Encodes a receptor tyrosine kinase Lymphomas (5)
alk/npm Translocation creates fusion protein with nucleophosmin(npm) Large cell lymphomas (5)
aml1 Encodes a transcription factor Acute myeloid leukemia (3)
aml1/mtg8 New fusion protein created by translocation Acute leukemias (3)
axl Encodes a receptor tyrosine kinase Hematopoietic cancers (3)
bcl-2, 3, 6 Block apoptosis (programmed cell death) B-cell lymphomas and leukemias (2)(3)
bcr/abl New protein created by fusion of bcr and abl triggers unregulated cell growth Chronic myelogenous and acute lymphotic leukemia (1)(2)
c-myc Transcription factor that promotes cell proliferation and DNA synthesis Leukemia; breast, stomach, lung, cervical, and colon carcinomas; neuroblastomas and glioblastomas (6)
dbl Guanine nucleotide exchange factor Diffuse B-cell lymphoma (3)
dek/can New protein created by fusion Acute myeloid leukemia (3)
E2A/pbx1 New protein created by fusion Acute pre B-cell leukemia (3)
egfr Cell surface receptor that triggers cell growth through tyrosine kinase activity Squamous cell carcinoma (1)(2)
enl/hrx Fusion protein created by a translocation t(11;19). Acute leukemias (3)
erg/TLS Fusion protein created by t(16:21) translocation.  The erg protein is a transcription factor. Myeloid leukemia (2)(3)

Cell surface receptor that triggers cell growth through tyrosine kinase activity

Glioblastomas, and squamous cell carcinomas (1)
erbB-2 Cell surface receptor that triggers cell growth through tyrosine kinase activity; also known as HER2 or neu Breast, salivary gland, and ovarian carcinomas (1)(4)
ets-1 Transcription factor Lymphoma (7)
ews/fli-1 Fusion protein created by  t(11:22) translocation. Ewing Sarcoma (2)(7)
fms Tyrosine kinase Sarcoma (8)
fos Transcription factor for API Osteosarcoma (2)(9)
fps Tyrosine kinase Sarcoma (8)
gli Transcription factor Glioblastoma (10)
gsp Membrane associated G protein Thyroid carcinoma (9)
HER2/neu overexpression of signaling kinase due to gene amplification Breast and cervical carcinomas (1)(9)
hox11 Transcription factor Acute T-cell leukemia (3)
hst Encodes fibroblast growth factor Breast and squamous cell carcinomas (3)
IL-3 Cell signaling molecule Acute pre B-cell leukemia (3)
int-2 Encodes a fibroblast growth factor Breast and squamous cell carcinomas (3)
jun Transcription factor for API Sarcoma (4)(9)
kit Tyrosine kinase Sarcoma (4)(9)
KS3 Herpes virus encoded growth factor Kaposi's sarcoma (9)
K-sam Fibroblast growth factor receptor Stomach carcinomas (3)
Lbc Guanine nucleotide exchange factor Myeloid leukemias (9)(11)
lck Tyrosine kinase T-cell lymphoma (9)
lmo1, lmo2 Transcription factors T-cell lymphoma (9)
L-myc Transcription factor Lung carcinomas (3)(4)
lyl-1 Transcription factor Acute T-cell leukemia (3)
lyt-10 Transcription factor.  Also called NFκB2 B-cell lymphoma (9)
lyt-10/C alpha1 Fusion protein formed by the (10;14)(q24;q32) translocation of lyt-10  next to  the C alpha 1 immunoglobulin locus.   (3)
mas Angiotensin receptor Mammary carcinoma (9)
mdm-2 Encodes a protein that inhibits and leads to the degradation of p53 Sarcomas (3)(4)
mll Transcription factor/methyltransferase (also called hrx and ALL1) Acute myeloid leukemia (2)(9)
mos Serine/threonine kinase Lung cancer (3)(12)
mtg8/aml1 Fusion of transcription repressor to factor to a transcription factor.  AML1 is also known as RUNX1. Acute leukemias (3)
myb Transcription factor Colon carcinoma and leukemias (3)
MYH11/CBFB New protein created by fusion of transcription factors via an inversion in chromosome 16. Acute myeloid leukemia (3)
neu Tyrosine kinase.  Also called erbB-2 or HER2 Glioblastomas, and squamous cell carcinomas (1)(3)
N-myc Cell proliferation and DNA synthesis Neuroblastomas, retinoblastomas, and lung carcinomas (1)(3)
ost Guanine nucleotide exchange factor Osteosarcomas (9)
pax-5 Transcription factor Lympho-plasmacytoid B-cell lymphoma (9)
pbx1/E2A Fusion protein formed via t(1:19) translocation. Transcription factor Acute pre B-cell leukemia (3)
pim-1 Serine/threonine kinase T-cell lymphoma (9)
PRAD-1 Encodes cyclin D1.  Involved in cell cycle regulation. Breast and squamous cell carcinomas (3)
raf Serine/threonine kinase Many cancer types (3)
RAR/PML Fusion protein caused by t(15:17) translocation.  Retinoic acid receptor. Acute premyelocytic leukemia (1)(3)
rasH G-protein. Signal transduction. Bladder carcinoma (3)
rasK G-protein. Signal transduction Lung, ovarian, and bladder carcinoma (3)(4)
rasN G-protein. Signal transduction Breast carcinoma (3)
rel/nrg Fusion protein formed by deletion in chromosome 2. Transcription factor. B-cell lymphoma (3)(4)
ret Cell surface receptor. Tyrosine kinase Thyroid carcinomas, multiple endocrine neoplasia type 2 (1)(3)
rhom1, rhom2 Transcription factors Acute T-cell leukemia (3)
ros Tyrosine kinase Sarcoma (9)
ski Transcription factor Carcinomas (9)
sis Growth factor Glioma, fibrosarcoma (9)
set/can Fusion protein formed by rearrangement of chromosome 9.  Protein localization Acute myeloid leukemia (9)(13)
src Tyrosine kinase Sarcomas (3)(14)
tal1, tal2 Transcription factor.TAL1 is also called SCL Acute T-cell leukemia (3)(15)
tan-1 Altered form of Notch (a cellular receptor) formed by t(7:9) translocation Acute T-cell leukemia (3)(16)
Tiam1 Guanine nucleotide exchange factor T-lymphoma (9)(17)
TSC2 GTPase activator Renal and brain tumors (9)(18)
trk Receptor tyrosine kinase Colon and thyroid carcinomas (3)(19)

* The cancer types listed in this column are those that are predominantly associated with each oncogene but this is not a complete list.

For information on these and other genes please visit the Cancer Genome Anatomy Project.

References for this page:
  1. Gustave Roussy, Cytogenomics of cancers: From chromosome to sequence, Molecular Oncology, Volume 4, Issue 4, August 2010, Pages 309-322 [PUBMED]
  2. Carlo M. Croce, M.D."Oncogenes and Cancer". N Engl J Med 2008; 358:502-511. [http://www.nejm.org/doi/full/10.1056/NEJMra072367]
  3. Cooper G. Oncogenes. Jones and Bartlett Publishers, 1995.
  4. Amplified and Over-expressed Genes in Cancer Table. The Institute of Cancer Research. 2009-2010. [http://www.amplicon.icr.ac.uk/table.php]
  5. Cheng M, Ott GR, Anaplastic lymphoma kinase as a therapeutic target in anaplastic large cell lymphoma, non-small cell lung cancer and neuroblastoma, Anticancer Agents Med Chem. 2010 Mar;10(3):236-49 [PUBMED]
  6. Hydbring P, Larsson LG, Tipping the balance: Cdk2 enables Myc to suppress senescence, Cancer Res. 2010 Sep 1;70(17):6687-91. Epub 2010 Aug 16. [PUBMED]
  7. Ordóñez JL, Osuna D, Herrero D, de Alava E, Madoz-Gúrpide J, Advances in Ewing's sarcoma research: where are we now and what lies ahead? Cancer Res. 2009 Sep 15;69(18):7140-50. Epub 2009 Sep 8 [PUBMED]
  8. Watowich SS, Liu YJ, Mechanisms regulating dendritic cell specification and development, Immunol Rev. 2010 Nov;238(1):76-92 [PUBMED]
  9. Vogelstein B, Kinzler KW. The Genetic Basis of Human Cancer. McGraw-Hill: 1998.
  10. Doi T, Puri P, Bannigan J, Thompson J, Disruption of GLI3-ZIC3 interaction in the cadmium-induced omphalocele chick model, Pediatr Surg Int. 2010 Nov 11 [PUBMED]
  11. Cerione RA, Zheng Y. "The Dbl family of oncogenes." Curr Opin Cell Biol (1996). 8(2): 216-22. [PUBMED]
  12. Gorgoulis VG, Zacharatos P, Mariatos G, Liloglou T, Kokotas S, Kastrinakis N, Kotsinas A, Athanasiou A, Foukas P, Zoumpourlis V, Kletsas D, Ikonomopoulos J, Asimacopoulos PJ, Kittas C, Field JK. "Deregulated expression of c-mos in non-small cell lung carcinomas: relationship with p53 status, genomic instability, and tumor kinetics." Cancer Res (2001). 61(2): 538-49. [PUBMED]
  13. Saito S, Miyaji-Yamaguchi M, Nagata K."Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export."Int J Cancer. 2004 Sep 10;111(4):501-7. [http://www.ncbi.nlm.nih.gov/pubmed/15239126] [PUBMED]
  14. Pene-Dumitrescu T, Smithgall TE."Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner."J Biol Chem. 2010 Jul 9;285(28):21446-57. Epub 2010 May 7. [http://www.ncbi.nlm.nih.gov/pubmed/20452982/] [PUBMED]
  15. O'Neil J, Shank J, Cusson N, Murre C, Kelliher M. "TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB."Cancer Cell. 2004 Jun;5(6):587-96. [http://www.ncbi.nlm.nih.gov/pubmed/15193261] [PUBMED]
  16. Pancewicz J, Taylor JM, Datta A, Baydoun HH, Waldmann TA, Hermine O, Nicot C."Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia."Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16619-24. Epub 2010 Sep 7. [http://www.ncbi.nlm.nih.gov/pubmed/20823234] [PUBMED]
  17. Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y. "CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells."J Biol Chem. 2010 May 14;285(20):15511-22. Epub 2010 Mar 9. [http://www.ncbi.nlm.nih.gov/pubmed/20215110] [PUBMED]
  18. Larson Y, Liu J, Stevens PD, Li X, Li J, Evers BM, Gao T. "Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1." J Biol Chem. 2010 Aug 6;285(32):24987-98. Epub 2010 Jun 8. [http://www.ncbi.nlm.nih.gov/pubmed/20530489] [PUBMED]
  19. Liraz Harel, Barbara Costa, Mike Fainzilber On the Death Trk Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel [http://www.ncbi.nlm.nih.gov/pubmed/20186708] [PUBMED]
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