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Oncogene Table

 

Oncogene Function/Activation Cancer* References
abl Promotes cell growth through tyrosine kinase activity Chronic myelogenous leukemia (1)(2)
Af4/hrx Fusion affects the hrx transcription factor/methyltransferase.  hrx is also called MLL, ALL1 and HTRX1 Acute leukemias (3)
akt-2 Encodes a protein-serine/threonine kinase Ovarian cancer (3)(4)
alk Encodes a receptor tyrosine kinase Lymphomas (5)
alk/npm Translocation creates fusion protein with nucleophosmin(npm) Large cell lymphomas (5)
aml1 Encodes a transcription factor Acute myeloid leukemia (3)
aml1/mtg8 New fusion protein created by translocation Acute leukemias (3)
axl Encodes a receptor tyrosine kinase Hematopoietic cancers (3)
bcl-2, 3, 6 Block apoptosis (programmed cell death) B-cell lymphomas and leukemias (2)(3)
bcr/abl New protein created by fusion of bcr and abl triggers unregulated cell growth Chronic myelogenous and acute lymphotic leukemia (1)(2)
c-myc Transcription factor that promotes cell proliferation and DNA synthesis Leukemia; breast, stomach, lung, cervical, and colon carcinomas; neuroblastomas and glioblastomas (6)
dbl Guanine nucleotide exchange factor Diffuse B-cell lymphoma (3)
dek/can New protein created by fusion Acute myeloid leukemia (3)
E2A/pbx1 New protein created by fusion Acute pre B-cell leukemia (3)
egfr Cell surface receptor that triggers cell growth through tyrosine kinase activity Squamous cell carcinoma (1)(2)
enl/hrx Fusion protein created by a translocation t(11;19). Acute leukemias (3)
erg/TLS Fusion protein created by t(16:21) translocation.  The erg protein is a transcription factor. Myeloid leukemia (2)(3)
erbB

Cell surface receptor that triggers cell growth through tyrosine kinase activity

Glioblastomas, and squamous cell carcinomas (1)
erbB-2 Cell surface receptor that triggers cell growth through tyrosine kinase activity; also known as HER2 or neu Breast, salivary gland, and ovarian carcinomas (1)(4)
ets-1 Transcription factor Lymphoma (7)
ews/fli-1 Fusion protein created by  t(11:22) translocation. Ewing Sarcoma (2)(7)
fms Tyrosine kinase Sarcoma (8)
fos Transcription factor for API Osteosarcoma (2)(9)
fps Tyrosine kinase Sarcoma (8)
gli Transcription factor Glioblastoma (10)
gsp Membrane associated G protein Thyroid carcinoma (9)
HER2/neu overexpression of signaling kinase due to gene amplification Breast and cervical carcinomas (1)(9)
hox11 Transcription factor Acute T-cell leukemia (3)
hst Encodes fibroblast growth factor Breast and squamous cell carcinomas (3)
IL-3 Cell signaling molecule Acute pre B-cell leukemia (3)
int-2 Encodes a fibroblast growth factor Breast and squamous cell carcinomas (3)
jun Transcription factor for API Sarcoma (4)(9)
kit Tyrosine kinase Sarcoma (4)(9)
KS3 Herpes virus encoded growth factor Kaposi's sarcoma (9)
K-sam Fibroblast growth factor receptor Stomach carcinomas (3)
Lbc Guanine nucleotide exchange factor Myeloid leukemias (9)(11)
lck Tyrosine kinase T-cell lymphoma (9)
lmo1, lmo2 Transcription factors T-cell lymphoma (9)
L-myc Transcription factor Lung carcinomas (3)(4)
lyl-1 Transcription factor Acute T-cell leukemia (3)
lyt-10 Transcription factor.  Also called NFκB2 B-cell lymphoma (9)
lyt-10/C alpha1 Fusion protein formed by the (10;14)(q24;q32) translocation of lyt-10  next to  the C alpha 1 immunoglobulin locus.   (3)
mas Angiotensin receptor Mammary carcinoma (9)
mdm-2 Encodes a protein that inhibits and leads to the degradation of p53 Sarcomas (3)(4)
mll Transcription factor/methyltransferase (also called hrx and ALL1) Acute myeloid leukemia (2)(9)
mos Serine/threonine kinase Lung cancer (3)(12)
mtg8/aml1 Fusion of transcription repressor to factor to a transcription factor.  AML1 is also known as RUNX1. Acute leukemias (3)
myb Transcription factor Colon carcinoma and leukemias (3)
MYH11/CBFB New protein created by fusion of transcription factors via an inversion in chromosome 16. Acute myeloid leukemia (3)
neu Tyrosine kinase.  Also called erbB-2 or HER2 Glioblastomas, and squamous cell carcinomas (1)(3)
N-myc Cell proliferation and DNA synthesis Neuroblastomas, retinoblastomas, and lung carcinomas (1)(3)
ost Guanine nucleotide exchange factor Osteosarcomas (9)
pax-5 Transcription factor Lympho-plasmacytoid B-cell lymphoma (9)
pbx1/E2A Fusion protein formed via t(1:19) translocation. Transcription factor Acute pre B-cell leukemia (3)
pim-1 Serine/threonine kinase T-cell lymphoma (9)
PRAD-1 Encodes cyclin D1.  Involved in cell cycle regulation. Breast and squamous cell carcinomas (3)
raf Serine/threonine kinase Many cancer types (3)
RAR/PML Fusion protein caused by t(15:17) translocation.  Retinoic acid receptor. Acute premyelocytic leukemia (1)(3)
rasH G-protein. Signal transduction. Bladder carcinoma (3)
rasK G-protein. Signal transduction Lung, ovarian, and bladder carcinoma (3)(4)
rasN G-protein. Signal transduction Breast carcinoma (3)
rel/nrg Fusion protein formed by deletion in chromosome 2. Transcription factor. B-cell lymphoma (3)(4)
ret Cell surface receptor. Tyrosine kinase Thyroid carcinomas, multiple endocrine neoplasia type 2 (1)(3)
rhom1, rhom2 Transcription factors Acute T-cell leukemia (3)
ros Tyrosine kinase Sarcoma (9)
ski Transcription factor Carcinomas (9)
sis Growth factor Glioma, fibrosarcoma (9)
set/can Fusion protein formed by rearrangement of chromosome 9.  Protein localization Acute myeloid leukemia (9)(13)
src Tyrosine kinase Sarcomas (3)(14)
tal1, tal2 Transcription factor.TAL1 is also called SCL Acute T-cell leukemia (3)(15)
tan-1 Altered form of Notch (a cellular receptor) formed by t(7:9) translocation Acute T-cell leukemia (3)(16)
Tiam1 Guanine nucleotide exchange factor T-lymphoma (9)(17)
TSC2 GTPase activator Renal and brain tumors (9)(18)
trk Receptor tyrosine kinase Colon and thyroid carcinomas (3)(19)

* The cancer types listed in this column are those that are predominantly associated with each oncogene but this is not a complete list.

For information on these and other genes please visit the Cancer Genome Anatomy Project.

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Last Modified: 07/15/2011 Print Email Page
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