Oncogene Table

Oncogene	Function/Activation	Cancer*	References
abl	Promotes cell growth through tyrosine kinase activity	Chronic myelogenous leukemia	⁽¹⁾⁽²⁾
Af4/hrx	Fusion affects the hrx transcription factor/methyltransferase. hrx is also called MLL, ALL1 and HTRX1	Acute leukemias	⁽³⁾
akt-2	Encodes a protein-serine/threonine kinase	Ovarian cancer	⁽³⁾⁽⁴⁾
alk	Encodes a receptor tyrosine kinase	Lymphomas	⁽⁵⁾
alk/npm	Translocation creates fusion protein with nucleophosmin(npm)	Large cell lymphomas	⁽⁵⁾
aml1	Encodes a transcription factor	Acute myeloid leukemia	⁽³⁾
aml1/mtg8	New fusion protein created by translocation	Acute leukemias	⁽³⁾
axl	Encodes a receptor tyrosine kinase	Hematopoietic cancers	⁽³⁾
bcl-2, 3, 6	Block apoptosis (programmed cell death)	B-cell lymphomas and leukemias	⁽²⁾⁽³⁾
bcr/abl	New protein created by fusion of bcr and abl triggers unregulated cell growth	Chronic myelogenous and acute lymphotic leukemia	⁽¹⁾⁽²⁾
c-myc	Transcription factor that promotes cell proliferation and DNA synthesis	Leukemia; breast, stomach, lung, cervical, and colon carcinomas; neuroblastomas and glioblastomas	⁽⁶⁾
dbl	Guanine nucleotide exchange factor	Diffuse B-cell lymphoma	⁽³⁾
dek/can	New protein created by fusion	Acute myeloid leukemia	⁽³⁾
E2A/pbx1	New protein created by fusion	Acute pre B-cell leukemia	⁽³⁾
egfr	Cell surface receptor that triggers cell growth through tyrosine kinase activity	Squamous cell carcinoma	⁽¹⁾⁽²⁾
enl/hrx	Fusion protein created by a translocation t(11;19).	Acute leukemias	⁽³⁾
erg/TLS	Fusion protein created by t(16:21) translocation. The erg protein is a transcription factor.	Myeloid leukemia	⁽²⁾⁽³⁾
erbB	Cell surface receptor that triggers cell growth through tyrosine kinase activity	Glioblastomas, and squamous cell carcinomas	⁽¹⁾
erbB-2	Cell surface receptor that triggers cell growth through tyrosine kinase activity; also known as HER2 or neu	Breast, salivary gland, and ovarian carcinomas	⁽¹⁾⁽⁴⁾
ets-1	Transcription factor	Lymphoma	⁽⁷⁾
ews/fli-1	Fusion protein created by t(11:22) translocation.	Ewing Sarcoma	⁽²⁾⁽⁷⁾
fms	Tyrosine kinase	Sarcoma	⁽⁸⁾
fos	Transcription factor for API	Osteosarcoma	⁽²⁾⁽⁹⁾
fps	Tyrosine kinase	Sarcoma	⁽⁸⁾
gli	Transcription factor	Glioblastoma	⁽¹⁰⁾
gsp	Membrane associated G protein	Thyroid carcinoma	⁽⁹⁾
HER2/neu	overexpression of signaling kinase due to gene amplification	Breast and cervical carcinomas	⁽¹⁾⁽⁹⁾
hox11	Transcription factor	Acute T-cell leukemia	⁽³⁾
hst	Encodes fibroblast growth factor	Breast and squamous cell carcinomas	⁽³⁾
IL-3	Cell signaling molecule	Acute pre B-cell leukemia	⁽³⁾
int-2	Encodes a fibroblast growth factor	Breast and squamous cell carcinomas	⁽³⁾
jun	Transcription factor for API	Sarcoma	⁽⁴⁾⁽⁹⁾
kit	Tyrosine kinase	Sarcoma	⁽⁴⁾⁽⁹⁾
KS3	Herpes virus encoded growth factor	Kaposi's sarcoma	⁽⁹⁾
K-sam	Fibroblast growth factor receptor	Stomach carcinomas	⁽³⁾
Lbc	Guanine nucleotide exchange factor	Myeloid leukemias	⁽⁹⁾⁽¹¹⁾
lck	Tyrosine kinase	T-cell lymphoma	⁽⁹⁾
lmo1, lmo2	Transcription factors	T-cell lymphoma	⁽⁹⁾
L-myc	Transcription factor	Lung carcinomas	⁽³⁾⁽⁴⁾
lyl-1	Transcription factor	Acute T-cell leukemia	⁽³⁾
lyt-10	Transcription factor. Also called NFκB2	B-cell lymphoma	⁽⁹⁾
lyt-10/C alpha1	Fusion protein formed by the (10;14)(q24;q32) translocation of lyt-10 next to the C alpha 1 immunoglobulin locus.		⁽³⁾
mas	Angiotensin receptor	Mammary carcinoma	⁽⁹⁾
mdm-2	Encodes a protein that inhibits and leads to the degradation of p53	Sarcomas	⁽³⁾⁽⁴⁾
mll	Transcription factor/methyltransferase (also called hrx and ALL1)	Acute myeloid leukemia	⁽²⁾⁽⁹⁾
mos	Serine/threonine kinase	Lung cancer	⁽³⁾⁽¹²⁾
mtg8/aml1	Fusion of transcription repressor to factor to a transcription factor. AML1 is also known as RUNX1.	Acute leukemias	⁽³⁾
myb	Transcription factor	Colon carcinoma and leukemias	⁽³⁾
MYH11/CBFB	New protein created by fusion of transcription factors via an inversion in chromosome 16.	Acute myeloid leukemia	⁽³⁾
neu	Tyrosine kinase. Also called erbB-2 or HER2	Glioblastomas, and squamous cell carcinomas	⁽¹⁾⁽³⁾
N-myc	Cell proliferation and DNA synthesis	Neuroblastomas, retinoblastomas, and lung carcinomas	⁽¹⁾⁽³⁾
ost	Guanine nucleotide exchange factor	Osteosarcomas	⁽⁹⁾
pax-5	Transcription factor	Lympho-plasmacytoid B-cell lymphoma	⁽⁹⁾
pbx1/E2A	Fusion protein formed via t(1:19) translocation. Transcription factor	Acute pre B-cell leukemia	⁽³⁾
pim-1	Serine/threonine kinase	T-cell lymphoma	⁽⁹⁾
PRAD-1	Encodes cyclin D1. Involved in cell cycle regulation.	Breast and squamous cell carcinomas	⁽³⁾
raf	Serine/threonine kinase	Many cancer types	⁽³⁾
RAR/PML	Fusion protein caused by t(15:17) translocation. Retinoic acid receptor.	Acute premyelocytic leukemia	⁽¹⁾⁽³⁾
rasH	G-protein. Signal transduction.	Bladder carcinoma	⁽³⁾
rasK	G-protein. Signal transduction	Lung, ovarian, and bladder carcinoma	⁽³⁾⁽⁴⁾
rasN	G-protein. Signal transduction	Breast carcinoma	⁽³⁾
rel/nrg	Fusion protein formed by deletion in chromosome 2. Transcription factor.	B-cell lymphoma	⁽³⁾⁽⁴⁾
ret	Cell surface receptor. Tyrosine kinase	Thyroid carcinomas, multiple endocrine neoplasia type 2	⁽¹⁾⁽³⁾
rhom1, rhom2	Transcription factors	Acute T-cell leukemia	⁽³⁾
ros	Tyrosine kinase	Sarcoma	⁽⁹⁾
ski	Transcription factor	Carcinomas	⁽⁹⁾
sis	Growth factor	Glioma, fibrosarcoma	⁽⁹⁾
set/can	Fusion protein formed by rearrangement of chromosome 9. Protein localization	Acute myeloid leukemia	⁽⁹⁾⁽¹³⁾
src	Tyrosine kinase	Sarcomas	⁽³⁾⁽¹⁴⁾
tal1, tal2	Transcription factor.TAL1 is also called SCL	Acute T-cell leukemia	⁽³⁾⁽¹⁵⁾
tan-1	Altered form of Notch (a cellular receptor) formed by t(7:9) translocation	Acute T-cell leukemia	⁽³⁾⁽¹⁶⁾
Tiam1	Guanine nucleotide exchange factor	T-lymphoma	⁽⁹⁾⁽¹⁷⁾
TSC2	GTPase activator	Renal and brain tumors	⁽⁹⁾⁽¹⁸⁾
trk	Receptor tyrosine kinase	Colon and thyroid carcinomas	⁽³⁾⁽¹⁹⁾

* The cancer types listed in this column are those that are predominantly associated with each oncogene but this is not a complete list.

For information on these and other genes please visit the Cancer Genome Anatomy Project.

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Last Modified: 07/15/2011

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References for this page:

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