TP53:
p53 is a tumor suppressor gene in charge of regulating cell division and apoptosis. About half of all human tumors have a mutation in the TP53 tumor suppressor gene. Several studies have reported that mutations in p53 have a critical role in the development of HCC.(1)
pRb:
pRb is a tumor suppressor gene. Together with TP53 it regulates cell division. the disruptionof the pRb pathway in HCC is similar to that of other cancers. (2)
Ras:
The human ras protein family is a family of proteins that drive cell division.
A recent study reported that some of the Ras family inhibitor are inactivated in human HCC, demonstrating the role of Ras pathway signals in liver cancer. (1)
NOTCH 2:
The NOTCH family is involved in several cell functions, such as proliferation, differentiation and cell death (apoptosis).(3)Hepatoblastoma can be the result of more than one type of translocation in the long arm (q) of chromosome 1. The NOTCH 2 protein has been found to delay the maturation of hepatoblasts during liver development; its expression is associated to the differentiation of the hepatoblasts into hepatocytes and biliary cells. It is thought that NOTCH 2 contributes to hepatoblastoma by keeping a population of hepatoblasts from differentiating.(4)
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