How Cancer Spreads (Metastasis)

As described (more briefly) in the Hallmarks of Cancer section, metastasis is responsible for the great majority of deaths in cancer patients. This section details the steps by which cancer cells spread around the body and form new growths.

Click on one of the items or 'Next' to learn about how cancer spreads.

• Overview of Metastases
• Formation of Metastases
• Routes of Metastasis
  • Spread of Cancer through the Lymphatic System
  • Organ Targeting: Anatomic vs Seed & Soil Models
• How Metastases Form New Tumors
• Barriers to Metastasis
• Drugs That Target Metastasis
• Section Summary: Metastasis

Test your knowledge of how cancer spreads with an educational game:

• Know the Flow: Metastasis