 |
Generic Name: Toremifene
Brand Name(s): Fareston®
IUPAC: 2-[4-[(Z)-4-chloro-1,2-di(phenyl)but-1-enyl]phenoxy]-N,N-dimethylethanamine
FDA Approval: yes
Manufacturer Link
|
Usage: Toremifene is used in treating
metastatic breast cancers in postmenopausal women whose cancers have either not been classified as either
estrogen receptor positive or negative, or in those that have been determined to be estrogen receptor positive.
Toremifene is taken in tablet form usually just once a day.
Mechanism: Toremifene citrate (Fareston®) is a molecule that binds to estrogen receptors in breast cancers. By blocking estrogen molecules from binding sites, toremifene prevents estrogen's growth stimulating effects in the tumor. Drugs that act in this way are referred to anti-estrogens because they block the effects of estrogen in certain tissues.
Side Effects: Common side effects include hot flashes and sweating, nausea and vomiting, vaginal discharge, dizziness, swelling. Less commonly, some patients may experience vaginal bleeding and in the event of this should contact their physician.
There also is concern that in some tissues and organs of the body, other than the breast, where toremifene may act as an estrogen rather than an anti-estrogen, cell
proliferation may be induced that could result in tumor formation. It is still unclear if this drug may cause the proliferation of
endometrial (inner uterus) cells.
Print
Email Page
