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CancerQuest > Drugs > Thalidomide (THALOMID®)

Thalidomide (THALOMID®)

Generic Name: Thalidomide Brand Name(s): THALOMID® IUPAC: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione FDA Approval: yes Manufacturer Link

Usage: THALOMID®, in combination with dexamethasone, is indicated for the treatment of patients with newly diagnosed multiple myeloma.

Mechanism: Thalidomide was initially sold, outside the U.S., as a sedative and to treat morning sickness. The drug was withdrawn from the market when it was discovered that thalidomide caused major birth defects (it is a teratogen). Thalidomide has potent anti-inflammatory activity and blocks the development of blood vessels (angiogenesis).

Side Effects: The side effects of thalidomide include blood clots (thromboembolic events), drowsiness, damage to the nervous system (peripheral neuropathy), reduced white blood cell counts (neutropenia), constipation, and drops in blood pressure upon standing (orthostatic hypotension).

Contraindications: Thalidomide causes severe birth defects (i.e. it is a potent teratogen). Women who are pregnant or who might become pregnant can not use thalidomide unless they follow very strict guidelines to prevent pregnancy.