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CancerQuest > Drugs > Temsirolimus (Toricel®)

Temsirolimus (Toricel®)

Generic Name: Temsirolimus Brand Name(s): Toricel® IUPAC: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S, 23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24, 25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy- 3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]- 1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexameth 3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28, 29(4H,6H,31H)-pentone 42-[2,2-bis(hydroxymethyl)propionate] Identifiers FDA Approval: yes Manufacturer Link

Usage: Temsirolimus is approved for the treatment of advanced renal cell carcinoma.

Mechanism: Temsirolimus (Toricel®) is a kinase inhibitor that prohibits the function of the oncoprotein mTOR and inhibits cell division and tumor growth.

Side Effects: Side Effects include: Rash, Nausea, Weakness, Inflammation of mucous membranes, Anorexia, Anemia

Contraindications: Serious reactions to temsirolimus include: hypersensitivity reactions (flushing, chest pain and/or difficulty breathing), hyperglycemia, interstitial lung disease, elevated serum triglyceride and cholesterol levels, bowel perforation and renal failure. Women should avoid becoming pregnant while on temsirolimus treatment and men undergoing treatment should use barrier methods of contraception. Pregnant women should be advised that there is a potenial harm to the fetus as a result of temsirolimus treatment. Additionally, mothers should discontinue nursing infants during and immediately following treatment. CYP3A inhibitors, CYP3A inducers and St. John's Wort can all interfere with the blood concentration of temsirolimus.