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Generic Name: Raloxifene
Brand Name(s): EVISTA®
IUPAC: [6-hydroxy-2-(4-hydroxyphenyl)- benzothiophen-3-yl]- [4-[2-(1-piperidyl)ethoxy]phenyl] -methanone
FDA Approval: yes
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Usage: Raloxifene is used in post-menopausal women who are at high risk of invasive breast cancer or have osteoporosis in order to reduce their risk. Studies are being done to test its usefulness of breast cancer prevention in certain pre-menopausaual women. *
Mechanism: Raloxifene binds to
estrogen receptors, thereby blocking some estrogenic pathways and activating others.
Side Effects: Common side effects include hot flashes, leg cramps, swelling, flu-like symptoms, joint pain, sweating. More serious side effect include blood clots and dying from stroke. Women who have or have had blood clots in the legs, lung, or eyes should not take EVISTA®
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