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CancerQuest > Drugs > Palonosetron (Aloxi® )

Palonosetron (Aloxi® )

Generic Name: Palonosetron Brand Name(s): Aloxi® IUPAC: 3aR)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a, 4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one FDA Approval: yes Manufacturer Link

Usage: Palonosetron (Aloxi®) was approved by the FDA in 2003 to help prevent the nausea and vomiting sometimes caused by chemotherapy.

Mechanism: Palonosetron is a 5-HT3 receptor antagonist. It has a strong affinity for this receptor and little for any other type. Blocking this receptor prevents the activation of the vomiting reflex.

Side Effects: Common side effects include: headache, fatigue, diarrhea, dizziness, abdominal pain, trouble sleeping and constipation.