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Generic Name: Oxaliplatin
Brand Name(s): Eloxatin®
IUPAC: (1R,2R)-cyclohexane-1,2-diamine; oxalate; platinum(+2) cation
FDA Approval: yes
Manufacturer Link
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Usage: Oxaliplatin is primarily used in the treatment of
metastatic or recurrent colorectal cancer. Oxaliplatin is administered as an intravenous infusion.
Mechanism: Oxaliplatin (Eloxatin®) is an
alkylating agent that prevents
DNA replication and
transcription by causing cross-links between DNA bases.
Side Effects: Common side effects include neuropathy, tiredness, weakness, diarrhea, nausea and vomiting, abdominal pain, fever, loss of appetite, pain. Side effects may be different or more intense if taken with other drugs. Many patients do experience neuropathy which most commonly appears as spasms, tingling, or abnormal tongue sensations which may worsen in cold temperatures. The neuropathy may be either temporary or persist after treatment has been suspended. Oxaliplatin should not be taken by women who are pregnant and patients should not become pregnant while using this drug, as it may have harmful affects on the developing fetus. This drug may also have negative effects on fertility in the years following treatment.
Low blood cell counts may result from oxaliplatin treatment which makes it necessary for blood tests to be done before each infusion. Also, patients should notify their doctors if any signs of infection appear, such as, fever, persistent diarrhea, or cough.
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