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Generic Name: Mitomycin C
Brand Name(s): Mutamycin®
IUPAC: 6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate (ester)
FDA Approval: yes
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Usage: Mitomycin C (Mutamycin®) is an
alkylating agent used in treating several cancers including, gastric cancer, anal and colon cancer, breast cancer, non-small cell lung cancer, head and neck cancer, small bladder papillomas, pancreatic cancer, cervical cancer. Mitomycin C is administered intravenously.
Mechanism: Mitomycin C is an alkylating agent that binds to
DNA, causing cross-linking and inhibition of DNA synthesis.
Side Effects: Some less common side effects include: occasional mouth sores, kidney toxicity, and occasional pneumonitis. Birth defects are a possibility, therefore patients should not become pregnant or father a child during treatment with mitomycin. Also, patients planning to have children in the future should consult with their doctor before beginning treatment as this drug may cause sterility. Doctors should be informed of pre-existing conditions such as chickenpox, heart disease or heart failure, gout, shingles, kidney stones or liver disease as these health conditions could increase the incidence and severity of side effects. Patients receiving this treatment should also avoid immunizations due to treatment-induced immunosuppression.
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