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Generic Name: Lomustine
Brand Name(s): CeeNU®
IUPAC: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
FDA Approval: yes
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Usage: Lomustine (CeeNU®) is used in a variety of cancers. Malignancies for which lomustine is used include brain tumors, breast cancer, Hodgkin
lymphoma, pancreatic cancer, lung cancer, melanoma,
multiple myeloma, ovarian cancer. Lomustine is administered in pill form.
Mechanism: Lomustine forms reactive metabolites which cause cross-linking of
DNA and inhibition of DNA synthesis.
Side Effects: Common side effects include myelosupression, nausea and vomiting, birth defects, loss of appetite, weight loss, weakness, excessive bleeding, difficulty walking, diarrhea, lethargy. Women who are pregnant or thinking of becoming pregnant should not take this drug as birth defects are a possibility. There is also an increased tendency to bleed making it necessary that the person not take aspirin as it 'thins' the blood, further increasing bleeding potential. Lomustine may have a negative effects on the the immune system. Because of this, patients should not receive immunizations while being treated.
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