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CancerQuest > Drugs > Ibuprofen (Advil®, Motrin®)

Ibuprofen (Advil®, Motrin®)

Generic Name: Ibuprofen Brand Name(s): Advil®, Motrin® IUPAC: (RS)-2-(4-isobutylphenyl)propanoic acid FDA Approval: yes Manufacturer Link

Usage: Ibuprofen is an anti-inflammatory drug available in several generic forms and is also known by the brand names Advil® or Motrin®. It can be given as a tablet or a liquid, usually several times daily. Ibuprofen is an ingredient in combination with hydrocodone in the prescription drug Vicoprofen®.⁽¹⁾, ⁽²⁾

Mechanism: Ibuprofen binds to both the COX1 and COX2 enzymes in the treatment of mild pain.

Side Effects: The most common side effects of Ibuprofen are abdominal pain, heartburn, and nausea due to COX1 inhibition and increased problems in patients with ulcers. Treatment with ibuprofen was less commonly associated with dizziness and rash. Long term use of ibuprofen in high doses can result in kidney and liver toxicities.

References for this page:

1. PDR. Electronic Library". Volume 2003. Micromedex. Thomson Healthcare, 2003.
2. Drug Information for the Health Care Professional. Edition 22, Volume 1. Micromedex. Thomson Healthcare, 2002.