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CancerQuest > Drugs > Fludarabine (Fludara®)

Fludarabine (Fludara®)

Generic Name: Fludarabine Brand Name(s): Fludara® IUPAC: [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate FDA Approval: yes Manufacturer Link

Usage: Fludarabine (Fludara®) is a strong suppressor of bone marrow activity. It is important to monitor blood cell and platelet counts throughout the duration of treatment. ⁽¹⁾

Mechanism: Fludura phosphate inhibits DNA synthesis by blocking the activity of two key enzymes required in the process. Fludarabine (Fludara®) is a strong suppressor of bone marrow activity. It is important to monitor blood cell and platelet counts throughout the duration of treatment.

Side Effects: Common side effects include bone marrow suppression, fever and chills, fatigue, infection, nausea and vomiting, weakness. Fludarabine (Fludara®) should not be taken by women who are pregnant and patients should not become pregnant while using this drug, as it may have harmful affects on the developing fetus. It is still unclear if this drug may have effects on fertility after treatment has ended.

References for this page:

1. Fludara.. Prescribing Information. Berlex Laboratories. December, 2001. [http://www.fludara.com]