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CancerQuest > Drugs > Dexrazoxane Hydrochloride (Totect®)

Dexrazoxane Hydrochloride (Totect®)

Generic Name: Dexrazoxane Hydrochloride Brand Name(s): Totect® IUPAC: 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione FDA Approval: yes Manufacturer Link

Usage: Dexrazoxane Hydrochloride (Totect®) is used to treat tissue damage due to extravasation of intravenous anthracycline chemotherapy.

Mechanism: The the full mechanism of dexrazoxane activity is unknown, there is some evidence that it inhibits topoisomerase II, an enzyme involved in DNA replication and transcription of RNA .

Side Effects: Side Effects include: Nausea, Vomiting, Fever, Infection

Contraindications: Patients on dexrazoxane treatment can develop myelosuppression--decreased levels of platelets and red and white blood cells--and therefore should be closely monitored. Women who are nursing, pregnant, or plan to become pregnant should be warned that dexrazoxane poses a potential danger to the fetus or infant.