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Generic Name: Carboplatin
Brand Name(s): Paraplatin®
IUPAC: cyclobutane-1,1-dicarboxylic acid
FDA Approval: yes
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Usage: Carboplatin (Paraplatin®) is an
alkylating agent used to treat a variety of cancers. Malignancies for which carboplatin is used include: Ovarian cancer, Germ cell tumors, Head and neck cancer, Small cell and non-small cell lung cancer, Bladder cancer, Relapsed and refractory (resistant to ordinary treatment) acute
leukemia,
endometrial cancer. Carboplatin is usually administered intravenously.
Mechanism: Carboplatin creates fragmented
DNA, prevents DNA synthesis via cross-linking of DNA, and creates mutations in nucleotides.
Side Effects: Common side effects include decreased white blood cell count with increased risk of infection, decreased platelet count with increased risk of bleeding,
brittle hair, altered kidney function (at high doses), fetal abnormalities may occur if the patient is pregnant or becomes pregnant during treatment. It is important to note that treatment with carboplatin can have serious effects on the patient's fertility. If having children in the future is a concern, this should be discussed with the health care provider. Other complications or more severe side effects may arise if the patient has any of the following medical problems: chickenpox or exposure to chickenpox, gout, heart disease, congestive heart failure, shingles, kidney stones, or liver disease.
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