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CancerQuest > Drugs > Busulfan (Myleran®)

Busulfan (Myleran®)

Generic Name: Busulfan Brand Name(s): Myleran® IUPAC: 4-methylsulfonyloxybutyl methanesulfonate FDA Approval: yes Manufacturer Link

Usage: Busulfan is used to treat chronic myelogenous leukemia. Busulfan is usually administered as an oral tablet. ⁽¹⁾

Mechanism: Busulfan (Myleran®) is an alkylating agent that prevents DNA synthesis and transcription and induces (causes) nucleotide mutations.

Side Effects: The most common adverse effect of busulfan is bone marrow depression which results in altered blood cell counts. For this reason, cell counts are monitored frequently to avoid any more serious effects.

Contraindications: Busulfan should not be taken by women who are pregnant and patients should not become pregnant while using this drug, as it may have harmful affects on the developing fetus.

References for this page:

1. Myleran.. Prescribing Information. GlaxoSmithKline. April, 2003. [http://www.gsk.com]