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Generic Name: Bleomycin
Brand Name(s): Blenoxane®
IUPAC: 3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium
FDA Approval: yes
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Usage: Malignancies for which bleomycin is used include squamous cell carcinomas (including those of the head and neck, penis, cervix, and vulva), Hodgkin's disease,
non-Hodgkin's
lymphoma, testicular cancer. Bleomycin is usually administered by injection.
Mechanism: Bleomycin (Blenoxane®) is a mixture of
cytotoxic antibiotics taken from a
bacteria. It is thought to inhibit
DNA synthesis, and to a lesser degree
RNA and
protein synthesis. This action prevents cell division.
(1)
Side Effects: Possible pneumonitis which can progress to pulmonary fibrosis.
Contraindications: Usually not used for patients with decreased liver or kidney function.
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