There are numerous changes that must occur for a normal cell to become a cancer cell. Additional changes are needed for that single cell to form a tumor and then for that tumor to grow and spread. An excellent review article detailing a model of cancer growth and spread was written by Douglas Hanahan and Robert Weinberg.(1) The information covered in the following pages is detailed in their paper. Click on the links below or 'Next Page' to learn more about the 'Hallmarks of Cancer'.
More detailed information on these topics can be found in the Cancer Biology section of the site.